TMPRSS2-ERG Gene Fusion Causing ERG Overexpression Precedes Chromosome Copy Number Changes in Prostate Carcinomas, Paired HGPIN Lesions
TMPRSS2-ETS gene fusions have been found recurrently in prostate carcinomas, but not in the presumed precursor lesion, high-grade prostatic intraepithelial neoplasia (HGPIN).However, HGPIN lesions may share chromosomal changes with prostate Lotions cancer.To determine the relative order of genetic events in prostate carcinogenesis, we have analyzed