TMPRSS2-ERG GENE FUSION CAUSING ERG OVEREXPRESSION PRECEDES CHROMOSOME COPY NUMBER CHANGES IN PROSTATE CARCINOMAS, PAIRED HGPIN LESIONS

TMPRSS2-ERG Gene Fusion Causing ERG Overexpression Precedes Chromosome Copy Number Changes in Prostate Carcinomas, Paired HGPIN Lesions

TMPRSS2-ETS gene fusions have been found recurrently in prostate carcinomas, but not in the presumed precursor lesion, high-grade prostatic intraepithelial neoplasia (HGPIN).However, HGPIN lesions may share chromosomal changes with prostate Lotions cancer.To determine the relative order of genetic events in prostate carcinogenesis, we have analyzed

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PRC1 chromatin factors strengthen the consistency of neuronal cell fate specification and maintenance in C. elegans.

In the nervous system, the specific identity of a neuron is established and maintained by terminal selector transcription factors that directly activate large batteries of terminal differentiation genes and positively regulate their own expression via feedback loops.However, how this is achieved in a reliable manner despite noise in gene expression

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